Early-Onset Alzheimer's Disease - Clinical Genetic Testing
Clinical genetic testing for early-onset Alzheimer's disease is complex, as the condition can be caused by mutations in different genes. In the absence of present physical symptoms, genetic testing is considered "predictive," as a positive result is strongly indicative of an eventual diagnosis.
This testing is for medical, clinical purposes.
This testing is only available through offline genetic testing providers if indicated by further evaluation and consultation with a trained genetic professional. Use the zip code search box to find a trained genetic professional in your area.
Late-Onset Alzheimer's Disease - Clinical Predisposition Testing
Late-onset Alzheimer's disease is a multifactorial condition, as both genetic and non-genetic factors are likely to play a role in the development of this disease.
Clinical genetic testing for predisposition to Late-Onset Alzheimer's disease looks for the APOE gene variant associated with an increased genetic risk to develop this disease.
The clinical usefulness of this testing is debated.
This testing is available online at the Direct-to-Consumer Genetic Testing providers listed below.
This testing is also available through many offline genetic testing providers if indicated by further evaluation and consultation with a trained genetic professional. Use the zip code search box to find a trained genetic professional in your area.
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Mygenome Inc. is a direct to consumer genetic testing company. Limited information is available regarding this provider. Please visit the provider for more information.
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Late-Onset Alzheimer's Disease (as part of Whole Genome Scan)
Informational genetic testing for susceptibility to Late-Onset Alzheimer's disease may also be available as part of a whole genome scan.
Whole genome scanning looks for SNPs that are present throughout the entire genome that have been linked to susceptibility to a number of different health conditions and physical traits. A SNP is a genetic change in which one "letter" of DNA differs from the usual "letter" at that point in the DNA sequence. The number of conditions, traits, and SNPs tested for varies by provider.
Whole Genome Scanning (with susceptibility to Late-Onset Alzheimer's testing) is available online at the Direct to Consumer Genetic Testing providers listed below. A consultation with a trained genetic professional may be useful.
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Early-Onset Alzheimer's Disease - Selected Mutations (as part of Whole Genome Scan)
Early-onset Alzheimer's disease testing by whole genome scanning looks for selected
mutations in the gene(s) associated with the condition. Of note, this testing does not detect all known disease-causing mutations. Depending on the
methodology used, whole genome scanning is typically not as accurate
as conventional molecular genetic testing methods.
As such, individuals who are pregnant, have a personal or family history of the
disorder, or have a spouse who is a known carrier, may be better
candidates for conventional molecular testing methods. Test results
should be discussed with a genetic professional.
This testing is available online through the Direct-to-Consumer Genetic Testing providers listed below. A consultation with a trained genetic professional may be useful.
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Late-Onset Alzheimer's Disease - Informational Susceptibility Testing
SNP testing for susceptibility to late-onset Alzheimer's disease looks for a single SNP or multiple SNPs that have been linked to this trait. A SNP is a genetic change in which one "letter" of DNA differs from the usual "letter" at that point in the DNA sequence. The number of SNPs tested for varies by provider. At this point, this testing is considered for informational purposes only and is not a medical (clinical) genetic test.
Analysis of the APOE 4 gene variant known to be associated with late-onset Alzheimer's disease may also be included.
This testing is available online through the Direct-to-Consumer Genetic Testing providers listed below. A consultation with a trained genetic professional may be useful.
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