Alternative Names
Cancer of the bladder; Malignant tumor of urinary bladder; Urinary bladder cancer
Symptoms & Characteristics
Bladder cancer is a disease in which certain cells in the bladder become abnormal and multiply without control or order. The bladder is a hollow, muscular organ in the lower abdomen that stores urine until it is ready to be excreted from the body.
The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma (TCC). Bladder cancer may cause blood in the urine, pain during urination, frequent urination, or the feeling that one needs to urinate without results. These signs and symptoms are not specific to bladder cancer, however. They also can be caused by noncancerous conditions such as infections.
Treatment
Treatment for bladder cancer depends on the stage of the tumor, the severity of the symptoms, and the presence of other medical conditions.
How Common Is It?
In the United States, bladder cancer is the fourth most common type of cancer in men and the ninth most common cancer in women. About 45,000 men and 17,000 women are diagnosed with bladder cancer each year.
Genetics & Inheritance
As with most cancers, the exact causes of bladder cancer are not known; however, many risk factors are associated with this disease.
- Many of the major risk factors are environmental, such as smoking and exposure to certain industrial chemicals. Studies suggest that chronic bladder inflammation, a parasitic infection called schistosomiasis, and some medications used to treat cancer are other environmental risk factors associated with bladder cancer.
Bladder cancer is typically not inherited. Most often, tumors result from genetic mutations that occur in bladder cells during a person's lifetime. These noninherited genetic changes are called somatic mutations.
- Researchers have studied the effects of mutations in several genes, including FGFR3, RB1, HRAS, TP53, and TSC1, on the formation and growth of bladder tumors. Each of these genes plays a critical role in regulating cell division by preventing cells from dividing too rapidly or in an uncontrolled way. Alterations in these genes may help explain why some bladder cancers grow and spread more rapidly than others.
- Deletions of part or all of chromosome 9 are common events in bladder tumors. Researchers believe that several genes that control cell growth and division are probably located on chromosome 9.
Researchers are working to determine whether a loss of these genes plays a role in the development and progression of bladder cancer. Most of the genetic changes associated with bladder cancer develop in bladder tissue during a person's lifetime, rather than being inherited from a parent. Some people, however, appear to inherit a reduced ability to break down certain chemicals, which makes them more sensitive to the cancer-causing effects of tobacco smoke and industrial chemicals.
Part of this research also involves SNPs, which are small variations in a single "letter" of DNA that can be found throughout our entire genetic make-up. Researchers have proposed that specific SNPs may influence bladder cancer risk in some people. However, much of this research is considered preliminary and is often limited to specific ethnic groups. Further research is needed to replicate study findings across different ethnic groups and clearly establish associations.
Genetic Testing
Clinical genetic testing for predisposition to bladder cancer is unavailable. For more information about the genetics of bladder cancer, use our find a genetic professional directory to locate a trained genetic professional in your area.
Informational genetic testing for susceptibility to bladder cancer is available online (over the internet) as part of a whole genome scan. Whole genome scanning involves analyzing thousands of SNPs at once related to a number of different health conditions.
- At this point, many genetic professionals do not consider this testing clinically useful or medically relevant, but for informational purposes only. Go to the Tests tab to link to the best providers, compare providers and read provider reviews.
Support & More Information
More information can be found at: