> Home DNA Test Review Comparison

Use this ratings chart to review and compare the different genetic variations associated with Breast Cancer and tested by home DNA testing providers. These findings are the result of an independent comparison of personal genomic company public information.

Breast Cancer

Genetic Variation			Companies				References*
Chromosome or Locus	Gene	SNP	deCODEme	Navigenics	23andMe	Gene Essence	deCODEme	Navigenics	23andMe
16q12	TNRC9/TOX3	rs3803662					8	8	4,7,8
2q35		rs13387042				8	8
10	FGFR2	rs2981582					4	4
11p15	LSP1	rs3817198					4	4
2	CASP8	rs1045485						2
1p11		rs11249433					10
10	FGFR2	rs1219648							3,4,5,6
chr8.128424800		rs13281615						4
2	CASP8	rs17468277					2
10	FGFR2	rs2420946							3,4,5,6
5	MRPS30	rs4415084					9
5	MAP3K1	rs4700485					4
3	NEK10	rs4973768					1
8q24		rs672888					4
5	MAP3K1	rs889312						4
14	RAD51L1	rs999737					10

Genes analyzed by Pathway Genomics (specific SNPs not available)

CHEK2, PALB2, CASP8, MSRP30, FGFR2, ESR1, RNF146, TNRC9, LSP1, AKAP9, MAP3K1

*Research references cited by companies:

1. Ahmed, S et al. Nat Genet. 2009 Mar;41(3):324-8. Epub 2009 Feb 15.
2. Cox, A et al. Nat Genet. 2007 Mar;39(3):352-8. Epub 2007 Feb 11.
3. Dickson et al. (2000) Breast Cancer Res 2(3):191-6.
4. Easton, DF et al. Nature. 2007 Jun 28;447(7148).
5. Hunter et al. (2007) Nat Genet 39(7):870-4.
6. Moffa and Ethier (2007) J Cell Physiol 210(3):720-31.
7. Smid et al. (2006) J Clin Oncol 24(15):2261-7.
8. Stacey, SN et al. Nat Genet. 2007 Jul;39(7):865-9.
9. Stacey, SN et al. Nat Genet. 2008 Jun;40(6):703-6.
10. Thomas, G et al. Nat Genet. 2009 Mar 29.

Sources:

http://demo.decodeme.com/health-watch/details/BCRS

https://www.23andme.com/you/journal/breastcancer/techreport/

http://www.navigenics.com/demo/for_scientists/d/breast_cancer/