> Home DNA Test Review Comparison

Use this ratings chart to review and compare the different genetic variations associated with Colorectal Cancer and tested by home DNA testing providers. These findings are the result of an independent comparison of personal genomic company public information.

Colorectal Cancer

Genetic Variation			Companies				References*
Chromosome or Locus	Gene	SNP	deCODEme	Navigenics	23andMe	Gene Essence	deCODEme	Navigenics	23andMe
8q24	POU5F1P1	rs6983267					7	2	2,7,10
11q23	LOC120376	rs3802842					6	6	5,6
18	SMAD7	rs4939827					1	1	1,6,8,9
8	EIF3H	rs16892766					8	8
15	CRAC1	rs4779584					4	4
		rs10505477
10p14		rs10795668					8
14	BMP4	rs4444235					3
20p12		rs961253					3

Genes analyzed by Pathway Genomics (specific SNPs not available)

RHPN2, EIF3H, BMP4, CRAC1, SMAD7, CDH1

*Research references cited by companies:

1. Broderick, P et al. Nat Genet. 2007 Nov;39(11):1315-7
2. Haiman et al. (2007) Nat Genet 39(8):954-6
3. Houlston, RS et al. Nat Genet. 2008 Dec;40(12):1426-35
4. Jaeger, E et al. Nat Genet. 2008 Jan;40(1):26-8
5. Pittman et al. (2008) Hum Mol Genet 17: 3720-3727
6. Tenesa, A et al. Nat Genet. 2008 May;40(5):631-7
7. Tomlinson, IP et al. Nat Genet. 2007 Aug;39(8):984-8
8. Tomlinson, IP et al. Nat Genet. 2008 May;40(5):623-30
9. Xu et al. (2007) Hum Mol Genet 16(SPEC):R14-20
10. Zanke et al. (2007) Nat Genet 39(8):989-994

Sources:

http://demo.decodeme.com/health-watch/details/CRC

https://www.23andme.com/you/journal/colorectalcancer/techreport/

http://www.navigenics.com/demo/for_scientists/d/colon_cancer/

http://www.geneessence.com/bmsa_0000/bmsa0000/crc.html