Use this ratings chart to review and compare the different genetic variations associated with
Crohn's Disease and tested by home DNA testing providers. These findings are the result of an independent comparison of personal genomic company public information.
| Genetic Variation | Companies | References* |
Chromosome or Locus
| Gene
| SNP
| deCODEme | Navigenics | 23andMe | Gene Essence | deCODEme | Navigenics | 23andMe |
| 5p13 |
PTGER4 |
rs17234657 |
 |
|
|
|
14 |
22 |
11,14,17,22 |
| 10q21 |
ZNF365 |
rs10761659 |
|
|
|
|
| 22 |
4,22 |
| 1 |
IL23R(1) |
rs11209026 |
| |
|
|
2 | | 2,11,21,22 |
| 18 |
PTPN2 |
rs2542151 |
|
|
| |
1 |
22 |
|
| 3 |
BSN |
rs9858542 |
|
| | |
14 |
22 | |
| |
IRGM |
rs1000113 |
| |
|
|
| 22 |
|
| 2 |
ATG16L1 |
rs10210302 | |
| | | | 22 | |
| chr10.101277754 |
|
rs10883365 |
| |
| |
| 22 |
|
| 10 |
NKX2-3 |
rs11190140 |
|
|
| | 14 |
|
14,22 |
| 1 |
IL23R |
rs11805303 |
|
|
| |
| 22 |
|
| 7p12 |
|
rs1456893 |
|
| | | 1 |
1 | |
| 8q24 |
|
rs1551398 |
|
|
| | 1 |
1 |
|
| 16 |
NOD2 |
rs2066844 | |
|
| | |
15 |
5,7,9,10,11,13,16,22 |
| 16 |
NOD2 |
rs2066845 |
| |
|
| | 15 |
5,7,9,10,11,13,16,22 |
| 16 |
NOD2 |
rs2066847 | |
|
| | |
15 |
5,7,9,10,11,13,16,22 |
| 10q21 |
|
rs224136 |
|
| | |
16 |
| |
| 2 |
ATG16L1 |
rs2241880 |
|
|
| | 8 |
|
8,16 |
| 6 |
CCR6 |
rs2301436 |
|
|
| | 1 |
1 |
|
| 17 |
ORMDL3 |
rs2872507 |
|
| | | 1 |
1 | |
| 13q14 |
|
rs3764147 |
|
|
| | 1 |
1 |
|
| 9 |
TNFSF15 |
rs4263839 |
|
| | |
1 |
1 | |
| 6 |
CDKAL1 |
rs6908425 |
|
| |
|
1 |
| |
| 17 |
STAT3 |
rs744166 |
|
| | |
1 |
1 | |
| 21 |
ICISLG |
rs762421 |
|
|
| | 1 |
1 |
|
| 6q21 |
|
rs7746082 |
|
| | |
1 |
1 | |
| 1q24 |
|
rs9286879 |
|
|
| | 1 |
1 |
|
| 5 |
IL12B |
rs10045431 |
|
| | |
1 |
|
|
| |
IL23R(2) |
rs1004819 |
| |
|
| | | 2,5 |
| |
|
rs10489629 | | | |
| | | |
| |
|
rs10512734 |
| | | |
| | |
| 9 |
JAK2 |
rs10758669 |
| | | |
1 | | |
| 1 |
IL23R |
rs10889677 |
|
| | | 2 |
| |
| |
LRRK2_MUC19 |
rs11175593 | |
| | | | 1 | |
| 1q32 |
|
rs11584383 |
| |
| | | 1 |
|
| |
|
rs12037606 | | | |
| | | |
| 1 |
KIF21B |
rs12122721 |
|
| | | 1 |
| |
| 5 |
IBD5 |
rs12521868 |
|
| | |
19 |
|
|
| |
|
rs13009506 |
| | | |
| | |
| 11 |
NELL1 |
rs1519717 |
| | | | 4 | | |
| |
|
rs17221417 |
| | | |
| | |
| 21q21 |
|
rs1736135 | |
| | | | 1 | |
| 21q21 |
|
rs1736148 |
|
| | | 1 |
| |
| 10p11 |
|
rs17582416 | |
| | | | 1 | |
| 11 |
NELL1 |
rs1793000 |
|
| | | 4 |
| |
| |
|
rs1793004 |
| | |
| | | |
| |
|
rs1799964 |
| | | |
| | |
| |
PTPN2 |
rs1893217 |
|
|
| | |
|
14,18,22,23 |
| 16 |
NOD2 |
rs2066843 |
|
| |
| 22 |
| |
| |
|
rs2076756 |
|
|
|
|
| | |
| |
|
rs2201841 |
| | | |
|
| |
| 1 |
ITLN1 |
rs2274910 |
| | | |
1 | | |
| |
|
rs2371685 |
| | |
|
| | |
| 1 |
PTPN22 |
rs2476601 | |
| | | | 1 | |
| |
|
rs2631372 |
| | | |
|
| |
| 3 |
MST1 |
rs3197999 | | | | | | | 1,6 |
| |
|
rs348594 |
| | |
|
| | |
| |
|
rs4821544 |
|
|
|
|
|
|
|
| 10p11 |
|
rs4934724 |
|
|
| | 1 |
| |
| 5 |
IRGM |
rs4958847 |
|
|
| | 14 | | |
| |
|
rs6596075 |
| |
|
|
| | |
| |
|
rs6601764 |
|
| | | | | |
| 1 |
PTPN22 |
rs6679677 |
|
| | | 1 |
| |
| |
IRGM |
rs7714584 |
| | | | | | 1,12,14,20 |
| |
|
rs7753394 |
|
| | |
| | |
| |
C11orf30 |
rs7927894 |
|
| | | | 1 | |
| |
|
rs8050910 |
|
| | |
| | |
| |
|
rs8111071 |
|
| | |
|
|
|
| |
|
rs9292777 |
|
|
|
|
|
| |
| |
|
rs9469220 | | |
|
| | | |
*Research references cited by companies:
1. Barrett, JC et al. Nat Genet. 2008 Aug;40(8):955-62. Epub 2008 Jun 29.
2. Duerr, RH et al. Science. 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26
3. Franke, A et al. PLoS ONE. 2007 Aug 8;2(1):e691.
4. Franke et al. (2008) Nat Genet 40(6):713-5.
5. Glas et al. (2007) PLoS ONE 2(9):e819.
6. Goyette er al. (2008) Mucosal Immunology 1:131–138.
7. Hampe et al. (2002) Lancet 359(9318):1661-5.
8. Hampe, J et al. Nat Genet. 2007 Feb;39(2):207-11. Epub 2006 Dec 31.
9. Hugot et al. (2001) Nature 411(6837):599-603.
10. Lesage et al. (2002) Am J Hum Genet 70(4):845-57.
11. Libioulle et al. (2007) PLoS Genet 3(4):e58.
12. McCarroll et al (2008) Nat Genet 40(9):1107-1112.
13. Ogura et al. (2001) Nature 411(6837):603-6.
14. Parkes, M et al. Nat Genet. 2007 Jul;39(7):830-2. Epub 2007 Jun 6.
15. Pascoe, L et al. Eur J Hum Genet. 2007 Aug;15(8):864-71. Epub 2007 Apr 25.
16. Rioux, JD et al. Nat Genet. 2007 May;39(5):596-604. Epub 2007 Apr 15.
17. Sheibanie et al. (2007) J Immunol 178(12):8138-47.
18. Simoncic et al. (2007) Curr Biol 12(6):446-53.
19. Silverberg, MS et al. Eur J Hum Genet. 2007 Mar;15(3):328-35. Epub 2007 Jan 10.
20. Singh et al. (2006) Science 313(5792):1438-41.
21. Van Limbergen et al. (2007) Gut 56(8):1173-4.
22. Wellcome trust Case Control Consortium. Nature. 2007 Jun 7;447(7145):661-78.
23. You-Ten et al. (1997) J Exp Med 22(16):5662-8.
Sources:
http://demo.decodeme.com/health-watch/details/IBD
https://www.23andme.com/you/journal/crohns/techreport/
http://www.navigenics.com/demo/for_scientists/d/crohns_disease/
http://www.geneessence.com/bmsa_0000/bmsa0000/cd.html
Last updated 01/22/2010
Please note that the information is not exhaustive, is based on cursory reviews of each personal genomic company's website and will be updated periodically.