> Home DNA Test Review Comparison

Use this ratings chart to review and compare the different genetic variations associated with Multiple Sclerosis and tested by home DNA testing providers. These findings are the result of an independent comparison of personal genomic company public information.

Multiple Sclerosis

Genetic Variation			Companies				References*
Chromosome or Locus	Gene	SNP	deCODEme	Navigenics	23andMe	Gene Essence	deCODEme	Navigenics	23andMe
5	IL7R	rs6897932					7	6	3,4,5,6,10,13,14
	IL2R	rs12722489						13
6	HLA-DRA	rs3135388					7		1,2,6,8,9,11,13
		rs10735781
		rs10975200
		rs10984447
		rs11164838
		rs12044852
		rs12487066
10	IL2RA	rs12722561					7
		rs2104286
		rs6498169
		rs6604026
		rs6680578
		rs7536563
		rs7577363
	DRB1*1501	rs9270986						12
		rs987106

 

*Research references cited by companies:

1. Barcellos et al. (2003) Am J Hum Genet 72(3):710-6.
2. Barcellos et al. (2006) Hum Mol Genet 15(18):2813-24.
3. Bielekova et al. (1999) J Neuroimmunol 100(1-2):115-23.
4. Correale et al. (2006) Neurology 67(4):652-9.
5. Cox et al. (2005) Eur J Immunol 35(11):3332-42.
6. Gregory SG et al. Nat Genet. 2007 Sep;39(9):1083-91. Epub 2007 Jul 29.
7. Hafler, DA et al. N Engl J Med. 2007 Aug 30;357(9):851-62. Epub 2007 Jul 29.
8. Haines et al. (1998) Hum Mol Genet 7(8):1229-34.
9. Kira (2003) Lancet Neurol 2(2):117-27.
10. Lundmark et al. (2007) Nat Genet 39(9):1108-13.
11. Oksenberg et al. (2004) Dev Biol 290(1):44-56.
12. Ramagopalan, SV et al. PLoS Genet. 2007 September; 3(9): e150.
13. The International Multiple Sclerosis Genetics Consortium (2007) Nat Genet 357(9):851-62.
14. Zhang et al. (2005) Genes Immun 6(2):145-52.

Sources:

http://demo.decodeme.com/health-watch/details/MS

https://www.23andme.com/you/journal/multiplesclerosis/techreport/

http://www.navigenics.com/demo/for_scientists/d/multiple_sclerosis/

http://www.geneessence.com/bmsa_0000/bmsa0000/ms.html