> Home DNA Test Review Comparison

Use this ratings chart to review and compare the different genetic variations associated with Prostate Cancer and tested by home DNA testing providers. These findings are the result of an independent comparison of personal genomic company public information.

Prostate Cancer

Genetic Variation			Companies				References*
Chromosome or Locus	Gene	SNP	deCODEme	Navigenics	23andMe	Gene Essence	deCODEme	Navigenics	23andMe
8q24 region 3	POU5F1P1	rs6983267					20	20	3,10,20,21,22
8q24 region 1		rs1447295					6	20	2,3,5,6,14,15,16,18,20,22
17q24.3		rs1859962					7	7	7,22
17q12	TCF2	rs4430796					7	7	7,22
7	JAZF1	rs10486567					17	17
8q24 region 2		rs10505483					6		3,6,10,13,19,22
11q13		rs10896449					17	17
8q24 region 2		rs16901979						6
8q24		rs10086908					1
2q31		rs10207654					4
		rs10763546
3q21.3		rs10934853					9
10	MSMB	rs10993994					17
		rs12079081
		rs12194182
8p21		rs1512268					4
8q24.21		rs16902104					9
		rs17562004
		rs1865866
3p12		rs2660753					11
2	EHBP1	rs2710646					8
19	KLK2/KLK3	rs2735839					11
5	TERT	rs401681					12
		rs4242382
		rs4242384
		rs4568789
		rs4962416						17
22q13		rs5759167					4
X	NUDT11	rs5945572					8
8q24.21		rs620861					9
7	LMTK2	rs6465657					11
		rs6465658
		rs6501455
		rs7109672
11p15		rs7127900					4
2p15		rs721048						8
4q24		rs7679673					4
		rs7814837
8q24 region 2		rs7817677							3,6,10,13,19,22
19q13.2		rs8102476					9
		rs902774
6	SLC22A3	rs9364554					11
		rs9643226

Genes analyzed by Pathway Genomics (specific SNPs not available)

JAZF1, MSMB, DAB21P, TERT, CLPTM1L, CTBP2, NUDT11, LMTK2, EHBP1, HNF1B, SLC22A3, TNRC6B

SNP analyzed by the Coriell Personalized Medicine Collaborative

rs16901979

*Research references cited by companies:

1. Al Olama AA, et al. Nat Genet. 2009 Sep 20.
2. Amundadottir et al. (2006) Nat Genet 38(6):652-8.
3. Cheng et al. (2008) Eur J Hum Genet Jan 30 [Epub ahead of print].
4. Eeles RA, et al. Nat Genet. 2009 Sep 20.
5. Freedman et al. (2006) Proc Natl Acad Sci U S A 103(38):14068-73.
6. Gudmundsson, J et al. Nat Genet. 2007 May;39(5):631-7. Epub 2007 Apr 1.
7. Gudmundsson, J et al. Nat Genet. 2007 Aug;39(8):977-83. Epub 2007 Jul 1.
8. Gudmundsson, J et al. Nat Genet. 2008 Mar;40(3):281-3. Epub 2008 Feb 10.
9. Gudmundsson J, et al. Nat Genet. 2009 Sep 20.
10. Haiman et al. (2007) Nat Genet 39(5):638-44.
11. Kote-Jarai, Z et al. Cancer Epid Biomarkers Prev. 2008 Aug;17(8):2052-61.
12. Rafnar, T et al. Nat Genet. 2009 Feb;41(2):221-7. Epub 2009 Jan 18.
13. Robbins et al. (2007) Genome Res [Epub ahead of print].
14. Schumacher et al. (2007) Cancer Res 67(7):2951-2956.
15. Severi et al. (2007) Cancer Epidemiol Biomarkers Prev 16(3):610-2.
16. Suuriniemi et al. (2007) Cancer Epidemiol Biomarkers Prev 16(4):809-14.
17. Thomas, G et al. Nat Genet. 2008 Mar;40(3):310-5. Epub 2008 Feb 10.
18. Wang et al. (2007) Cancer Res 67(7):2944-50.
19. Witte et al. (2007) Nat Genet 39(5):579-80.
20. Yeager, M et al. Nat Genet. 2007 May;39(5):645-9. Epub 2007 Apr 1.
21. Zheng et al. (2007) J Natl Cancer Inst 99(20):1525-33.
22. Zheng et al. (2008) N Engl J Med Jan 16 [Epub ahead of print].

Sources:

http://demo.decodeme.com/health-watch/details/PCA

https://www.23andme.com/you/journal/prostate/techreport/

http://www.navigenics.com/demo/for_scientists/d/prostate_cancer/

http://www.geneessence.com/bmsa_0000/bmsa0000/pc.html