> Home DNA Test Review Comparison

Use this ratings chart to review and compare the different genetic variations associated with Rheumatoid Arthritis and tested by home DNA testing providers. These findings are the result of an independent comparison of personal genomic company public information.

Rheumatoid Arthritis

Genetic Variation			Companies				References*
Chromosome or Locus	Gene	SNP	deCODEme	Navigenics	23andMe	Gene Essence	deCODEme	Navigenics	23andMe
1	PTPN22	rs2476601					2	2	2,3,5,7,8,12,13,14,16,17,18,23,24,29,31
9	trAF1/C5	rs3761847					18	19	4,6,11,18,20,28,30,33
6	MHC	rs6457617						31	18, 31
chr6.138048197		rs6920220						31
2	STAT4	rs7574865					21	21
		rs10118357
chr6.138007111		rs10499194						19
9		rs10733648
9	C5	rs10985112
		rs11162922
1	PADI4	rs11203366							9,10,22,25,26
		rs11203367
		rs11761231
RA_6q23		rs13192841					19
		rs1748035
		rs1930780
		rs2104286
		rs2240335
RA_6q23		rs2327832					19		1,18,20,27,31
		rs2416804
		rs3087243
		rs3765598
		rs3816587
	MMEL1	rs3890745							1,15,18,20,31
6	HLA-DRB1	rs660895					18
		rs6679677
		rs6684865
4	IL2 / IL21	rs6822844					32
		rs7026551
		rs743777
		rs7528684
		rs7582694
		rs9550642

*Research references cited by companies:

1. Barton et al. (2008) Nat Genet 40(10):1156-9.
2. Begovich, AB et al. Am J Hum Genet. 2004 Aug;75(2):330-7.
3. Bottini et al. (2004) Nat Genet 36(4):337-8.
4. Bradley and Pober (2001) Oncogene 20(44):6482-91.
5. Cloutier and Veillette (1999) J Exp Med 189(1):111-21.
6. Cooke et al. (1975) Arthritis Rheum 18(6):541-51.
7. Hinks et al. (2005) Arthritis Rheum 52(6):1694-9.
8. Hinks et al. (2007) Ann Rheum Dis 66(5):683-6.
9. Ikari et al. (2005) Arthritis Rheum 52(10):3054-7.
10. Kang et al. (2006) Arthritis Rheum 54(1):90-6.
11. Kurreeman et al. (2007) PLoS Med 4(9):e278.
12. Lee et al. (2005) Genes Immun 6(2):129-33.
13. Michou et al. (2007) Proc Natl Acad Sci U S A 104(5):1649-54.
14. Orozco et al. (2005) Arthritis Rheum 52(1):219-24.
15. Ouimet et al. (2000) Biochem Biophys Res Commun 271(3):565-70.
16. Pierer et al. (2006) Arthritis Res Ther 8(3):R75.
17. Plenge et al. (2005) Am J Hum Genet 77(6):1044-60.
18. Plenge, RM et al. N Engl J Med. 2007 Sep 20;357(12):1199-209.
19. Plenge, RM et al. Nat Genet. 2007 Dec;39(12):1477-82.
20. Raychaudhuri et al. (2008) Nat Genet 40(10):1216-23.
21. Remmers, EF et al. N Engl J Med. 2007 Sep 6;357(10):977-86.
22. Schellekens et al. (2000) Arthritis Rheum 43(1):155-63.
23. Simkins et al. (2005) Arthritis Rheum 52(7):2222-5.
24. Steer et al. (2005) Arthritis Rheum 52(1):358-60.
25. Suzuki et al. (2003) Nat Genet 34(4):395-402.
26. Takata et al. (2008) J Hum Genet 53(2):163-73.
27. Thomson et al. (2007) Nat Genet 39(12):1431-3.
28. Tsitsikov et al. (2001) Immunity 15(4):647-57.
29. van Oene et al. (2005) Arthritis Rheum 52(7):1993-8.
30. Wang et al. (2000) J Immunol 164(8):4340-7.
31. WTCCC, Nature. 2007 Jun 7;447(7145):661-78.
32. Zhernakova, A et al. Am J Hum Genet. 2007 Dec;81(6):1284-8.
33. Zvaifler (1973) Adv Immunol 16(0):265-336.

Sources:

http://demo.decodeme.com/health-watch/details/RA

https://www.23andme.com/you/journal/rheumarthritis/techreport/

http://www.navigenics.com/demo/for_scientists/d/rheumatoid_arthritis/

http://www.geneessence.com/bmsa_0000/bmsa0000/ra.html