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Pediatric researchers have found that the interplay of genes involved in diabetes and inflammatory bowel disease is more complex than previously thought. Both type 1 diabetes and Crohn's disease are autoimmune diseases. Autoimmune diseases often have some genes in common, but these two disorders seem to be closely related. Certain genes appear to raise the risk of type 1 diabetes, while lowering the risk for Crohn's.
After a large outbreak of post-infectious Inflammatory Bowel Syndrome in Walkerton, Canada, researchers have found a genetic link to susceptibility to the disease. Over 800 subjects, some infected and some controls, were compared, and three genes were found that can cause greater risk of IBS. The three genes involved cause a greater risk by causing a change in the way proteins that protect the intestines are encoded.

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